Hello. I'm a pharmacist Jinny.
Did you know that cardiovascular disease is the disease with the highest mortality rate in Korea, excluding cancer? In particular, the mortality rate of heart disease increases sharply after the age of 50. According to the 2021 Statistics on Causes of Death released by Statistics Korea, the mortality rate of heart disease and cerebrovascular disease among people in their 50s and older ranks 2~3 among all causes of death [1].
However, these cardiovascular diseases are more preventable than any other group of diseases. In other words, it can be improved to a large extent through lifestyle modifications.
So, today, I would like to introduce you to some food ingredients for blood circulation health that you can easily take. It is the nattokinase (hereinafter referred to as natto culture powder) contained in Japan's representative health food "natto". Natto is one of the world's top five health foods selected by < Health >, a global health magazine, and natto culture powder, which is the core of natto, is also a functional ingredient that has been recognized by the Ministry of Food and Drug Safety for its ability to improve blood circulation and regulate blood pressure.
In addition, several studies have shown that it can help reduce cardiovascular risk. We will explain in detail how NATO culture powder can have these benefits through human application tests.
Simvastatin is a drug used to reduce lipid levels and reduce the risk of various cardiovascular diseases such as myocardial infarction and stroke. Natobacteria culture powder is a raw material that has been reported to have clinical outcomes similar to those of these simvastatin drugs [2].
According to a review paper published in the International Journal of Molecular Sciences, NATO culture powder has been shown to improve blood circulation and reduce the risk of cardiovascular disease [3].
"Various animal and human studies have demonstrated that NK (natto culture powder) helps improve blood circulation and reduce the risk of various cardiovascular diseases without side effects."
So, how does this effect occur in NATO culture powder? This is because NATO culture powder reduces the possibility of blood clots forming.
A blood clot is a clot of blood in a blood vessel. When these clots block arteries, they can cause emergencies such as myocardial infarction, stroke, and pulmonary thrombosis. In this case, surgery and medication are used to remove the clot.
Natobacteria culture powder inhibits the formation of blood clots by reducing the production of fibrinogen, a protein that makes blood clots. In a 2009 clinical trial, 45 subjects who were given 2,000 fibrinolysis units per capsule/day for 2 months were shown to reduce fibrinogen concentrations [4].
"After two months of administration, fibrinogen, factor VII, and factor VIII decreased by 9%, 14%, and 17%, respectively, in the Healthy group."
Blood clots are not the only risk factor for cardiovascular disease. High blood pressure is also a risk factor that increases the risk of cardiovascular disease and death. In fact, 3 out of 10 Koreans over the age of 20 suffer from high blood pressure.
Natomycetto culture powder has also been shown to be effective in lowering blood pressure in various studies. In a 2008 clinical trial, 73 subjects with prehypertension or hypertension who were given 2,000 FU/capsule of natto culture powder daily for 8 weeks reduced both systolic and diastolic blood pressure [5].
"It was shown that NATO culture powder supplementation reduced both SBP (systolic blood pressure) and DBP (diastolic blood pressure)."
Today, we looked at the benefits of natto culture powder for blood circulation and blood pressure through research. In general, natto culture powder is a functional ingredient that can be eaten without major side effects. However, if you have hemophilia or are taking blood-thinning medications such as warfarin, it is recommended that you consult your doctor before taking it.
In addition, since it has the property of thinning the blood, it is recommended that you stop taking it at least 2 weeks before surgery to prevent excessive bleeding, even if you are planning surgery.
So, I hope you have a healthy day in body and mind. It was Jinny.
[1] Population Trends Division, Social Statistics Bureau, Statistics Korea. (2022, September 27). 2021 Cause of Death Statistics.
[2] Ren, n., chen, h., li, lin, y.,y., mcgowan, e., . (2017). A Clinical Study on the Effect of Nattokinase on Carotid Artery Atherosclerosis and Hyperlipidaemia. National Medical Journal of China, 97(26), 2038–2042.
[3] Weng, Yunqi; Yao, Jian; Sparks, Sawyer; Wang, Kevin (2017). Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. International Journal of Molecular Sciences, 18(3), 523.
[4] Chien-Hsun Hsia; Ming-Ching Shen; Jen-Shiou Lin; Yao-Ke Wen; Kai-Lin Hwang; Thau-Ming Cham; Nae-Cherng Yang (2009). Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutrition Research, 29(3), 190–196.
[5] GUM, Si Nae; PAIK, Jean Kyung; LIM, Hyo Hee; KIM, Kyong-Chol; OGASAWARA, Kazuya; INOUE, Kenichi; PARK, Sungha; JANG, Yangsoo; LEE, Jong Ho (2008). Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research, 31(8), 1583–1588.
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