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Pharmacist who reads papers
The main ingredient that relieves the side effects of antibiotics
Lactobacillus efficacy
Hello. I'm a pharmacist Jinny.
Recently, as concerns about infection have grown due to the coronavirus, criticism of excessive antibiotic prescriptions has received renewed attention. According to OECD analysis data, the average use of antibiotics in Korea is 27.9 (DDD/1,000 people/day), which is far higher than the OECD average of 20.5. Antibiotics have as many side effects as they are effective, so it is necessary to be vigilant against misuse.
Antibiotics do not distinguish between beneficial and harmful bacteria, so they not only eliminate harmful bacteria that invade the body, but also kill all the beneficial bacteria necessary to maintain intestinal balance. This disruption in the intestinal balance causes secondary consequences such as diarrhea, abdominal pain, vomiting, and fever. This is due to the fundamental properties of antibiotics.
It is commonly believed that lactobacillus is the main ingredient in relieving the side effects of antibiotics. This is the result of the process by which beneficial bacteria improve the intestinal environment that has been damaged by antibiotics. Just as there are various types of lactic acid bacteria, not all lactic acid bacteria have the same effect. For this reason, there has been a steady stream of efforts in academia to identify bacteria that specialize in improving the side effects of antibiotics.
Lactobacillus efficacy
In particular, I would like to briefly explain the well-known HOWARU RESTORE 4 types of mixture. This strain is sourced from DuPont, one of the world's leading hyphae. The HOWARU 4 mixed bacteria are considered to be the most well-documented species in that there are four mixed bacteria [1].
When one bacterium is added to another bacterium, it has different functions and characteristics, so the bacterial mix is very important.
"In particular, the incidence of diarrhea due to the use of antibiotics, the duration of diarrhea symptoms, and abdominal distension were found to be significantly reduced."
This paper is based on an experiment conducted on 503 patients who used antibiotics over a 5-month period. Notably, this study is one of the largest studies in terms of antibiotic side effects and is the only one that examined the response to the dose of lactobacillus. In particular, the authors demonstrated that HOWARU mixed strain intake reduced antibiotic-induced side effects even at low doses and was more effective in the high-dose group. However, the improvement effect is not proportional to the content unconditionally, so it is important to consume the right level, right?
This is a brief overview of the functions of lactic acid bacteria.
I hope you have a healthy day in body and mind. It was Jinny.
[1] Ouwehand, A. C., DongLian, C., Weijian, X., Stewart, M., Ni, J., Stewart, T., & Miller, L. E. (2014). Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine, 32(4), 458–463.
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