![[Lemon Balm Dandelion Extract Complex (LD100) Benefits] 3 Benefits of LD100, a high-tech ingredient that protects liver cells](http://esther-mall.com/cdn/shop/articles/65.jpg?v=1734030179&width=480)
It is a state-of-the-art liver health functional ingredient, LD100.
Hello. I'm a pharmacist Jinny.
When you think of liver health, what is the first ingredient that comes to mind? I'm sure many of you, including myself, reflexively thought of milk thistle. Milk thistle has been used in Europe since the 1st century to the 1st century as a treatment for jaundice, stone removal, and snakebites, and has been used as an adjunct treatment for liver diseases since 1968, when its active ingredient was identified [1].
In other words, for the past 50 years, the main ingredient in liver health has been milk thistle extract. However, in 2020, an interesting study was published in the Journal of Food Biochemistry, an SCI-level international journal. In suppressing alcohol-induced hepatic stetopathy, the high-tech ingredient 'this ingredient' showed a better effect than milk thistle extract (silymarin) [2].
If you are a frequent drinker, you should focus on this ingredient, which is the functional ingredient lemon balm dandelion extract complex (LD100) that we will introduce today. As the name suggests, this ingredient is a combination of lemon balm extract and dandelion extract in the ratio that showed the best activity in the test study, and it is also the latest individually recognized liver health functional ingredient recognized by the Ministry of Food and Drug Safety.
Now, let's take a look at the scientific research on lemon chestnut dandelion extract (LD100) to see what mechanism and test results have been confirmed that it is superior to milk thistle extract, which has been synonymous with liver health functional ingredients for 50 years.
Drinking alcohol is not bad in itself, but excessive alcohol consumption is one of the causes of ill health. In fact, in 3.8% of deaths worldwide, alcohol consumption is reported to be the primary cause of death. In particular, alcoholic liver disease is one of the important causes of death from liver disease, and is highly associated with increased alcohol consumption and time spent [3].
This may sound like a no-brainer, but in fact, studies have shown that more than 90% of people who drink heavily will develop fatty liver, and 30% will develop alcoholic liver disease. Acute · It is known to be caused by free radical production, mitochondrial damage, and steatosis [4], which are common features of chronic alcohol exposure [4].
For this reason, one of the most important items to consider in the efficacy of functional ingredients for liver health is their effectiveness in inhibiting liver damage caused by alcohol. In 2020, the Journal of Food Biochemistry, an SCI-level international journal, confirmed the protective effect of lemon balm dandelion extract complex (LD100) against alcoholic liver injury and announced that it was superior to milk thistle extract in terms of effectiveness [5].
"In the treatment of alcoholic liver damage, the hepatoprotective effect of lemon balm dandelion extract complex was superior to that of milk thistle extract and lemon balm and dandelion monoextract. ... This proves that lemon balm dandelion extract complex is a promising candidate for the prevention of alcohol-induced liver damage."\
Based on scientific reports of the superior hepatoprotective activity of Lemon Balm Dandelion Extract Complex (LD100) in alcoholic liver injury, further studies have been designed to examine whether the efficacy of this ingredient is limited to alcoholic liver damage or may contribute to the improvement of liver health on a broader scale, including in the reduction of liver health in general.
In this study, a 12-week clinical trial was conducted on 96 adults with liver levels of approximately 110~320% of the normal limit* despite not excessive alcohol consumption, liver disease, or taking other medications that may cause liver damage [6], and a significant reduction in AST and GGT, the main liver function test markers, was confirmed by the consumption of lemon balm dandelion extract complex (LD100) [6].
"Through this clinical trial, it was confirmed that the intake of LD100 500 mg/day for 12 weeks had the function of improving liver function by reducing blood AST and GGT in subjects with mild liver insufficiency. In addition, no clinically significant adverse reactions or physical changes were observed during the study, so the intake of LD100 was judged to be safe for the human body."
Earlier, I mentioned that fatty liver is observed in more than 90% of people who drink heavily. Fatty liver refers to the accumulation of fat in the liver cells, and excessive alcohol consumption · Obesity (abdominal obesity) · Diabetes · Hyperlipidemia is considered to be the main cause of fatty liver. It is very common, but it may not go unnoticed because there are no specific symptoms.
However, if the root cause of fatty liver is not corrected, it can progress to cirrhosis through steatohepatitis and liver fibrosis, so proper management is necessary. According to the mechanism study, lemon balm dandelion extract complex is expected to be helpful in the management of fatty liver by inhibiting the expression of liver lipid-forming genes and inhibiting the accumulation of liver lipids by increasing the expression of genes involved in liver lipid oxidation.
As early as 2019, Choi and his colleagues evaluated the impact of lemon balm dandelion extract complex on non-alcoholic acute liver injury induced by carbon tetrachloride. In this study, treatment with lemon balm dandelion extract complex (LD100) was associated with a reduction in liver relative weight, which was superior to milk thistle extract, lemon balm, and dandelion alone [7].
"Administration of lemon balm and dandelion leaf extract in mixed ratios statistically significantly inhibited the increase in hepatic relative weight due to liver toxicity, and ... Milk thistle extract (silymarin), lemon balm alone, and dandelion alone reduced liver relative weight more than the group."
Today, we've taken a look at some of the results of academic research on lemon balm dandelion extract complex (LD100), a new material for liver health. Antioxidant · Unlike milk thistle extract, which contributes to detoxification by enhancing the antioxidant activity of liver tissue based on its anti-inflammatory activity, lemon balm dandelion extract complex (LD100) is a combination of lemon balm extract, which acts on improving lipid metabolism, and antioxidant · It appears to contribute to liver health due to the synergistic action of dandelion extract, which has anti-inflammatory properties.
Based on the above, it is thought that if you want to intensively manage your liver health, you can choose Lemon Balm Dandelion Extract Complex (LD100), and if you want to reduce the burden of liver detoxification and help with antioxidants, you can choose Milk Thistle Extract, which will help you make good use of each ingredient in a more appropriate way for the purpose of intake.
In addition, both Milk Thistle Extract and Lemon Balm Dandelion Extract Complex (LD100) are recommended to be avoided in children under 12 years of age. In addition, if you are undergoing treatment for a medical condition or taking any medications, we recommend that you consult your doctor before deciding how to take them.
I hope you have a healthy day in body and mind. It was Jinny.
[1] Gillessen, A., & Schmidt, H. H. J. (2020). Silymarin as supportive treatment in liver diseases: A narrative review. Advances in therapy, 37(4), 1279-1301.
[2,5] Choi, B. R., Cho, I. J., Jung, S. J., Kim, J. K., Park, S. M., Lee, D. G., ... & Park, K. M. (2020). Lemon balm and dandelion leaf extract synergistically alleviate ethanol‐induced hepatotoxicity by enhancing antioxidant and anti‐inflammatory activity. Journal of Food Biochemistry, 44(8), e13232.
[3,4] Li, S., Tan, H. Y., Wang, N., Zhang, Z. J., Lao, L., Wong, C. W., & Feng, Y. (2015). The role of oxidative stress and antioxidants in liver diseases. International journal of molecular sciences, 16(11), 26087-26124.
[6] LD100 Clinical Application Test Report 'A 12-week, randomized, double-blind, placebo comparative clinical trial to evaluate the efficacy and safety of LD100 in improving liver function in subjects with mild liver insufficiency'
[7] Choi, B. R., Cho, I. J., Jung, S. J., Kim, J. K., Lee, D. G., Ku, S. K., & Park, K. M. (2019). Study on the hepatoprotective effects of lemon balm and dandelion leaf extract combination in carbon tetrachloride-mediated liver injured mice. Herbal formula science, 27(3), 199-211.
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