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Introducing the powerhouse of anti-aging, "this ingredient".
Hello. I'm a pharmacist Jinny.
Anti-aging, it's a magic word that really shakes the mind. Many people, including myself, are looking for an efficient way to delay skin aging, but I would like to introduce the mechanism of action and the results of the human body application test of the new skin health material 'Rosemary Extract Complex (SunMax)', which has recently been recognized by the Ministry of Food and Drug Safety as an individually recognized functional ingredient for skin health.
Theoretically approached, effective anti-aging requires two types of care. One is to supplement the three major elements of the dermis that decrease with the aging of the body, and the other is to prevent exogenous aging (photoaging) caused by ultraviolet rays as much as possible. That's why it's recommended to supplement collagen and elastin, which decline with age, and that's why dermatologists emphasize the importance of sunscreen.
So far, I have introduced ingredients that are beneficial in the management of endogenous aging, such as collagen, elastin, and salmon DNA, and ingredients that are beneficial in the management of exogenous aging, such as glutathione, but the ingredients that are beneficial in the management of exogenous aging are mainly based on antioxidant power, so I had no choice but to expect relatively indirect benefits. However, the functional ingredient that we will introduce today, Rosemary Extract and other compounds (SunMax) have not only been recognized for their ability to maintain skin health from photoaging. It is an ingredient that has been confirmed to improve the formation of 4 types of wrinkles in human application tests.
Let's take a closer look at the direct effects of these new anti-aging materials.
One of the most common signs of skin aging is wrinkles. Both endogenous and exogenous aging leave wrinkles, but if endogenous aging is characterized by fine wrinkles, ultraviolet radiation-induced exogenous aging is characterized by deep and thick wrinkles. Therefore, as an anti-aging ingredient that manages exogenous aging caused by ultraviolet rays, it can be said that the function of improving wrinkle formation is quite important.
As a result of a human body application test on adult men and women with wrinkles around the eyes or mild or severe nasolabial folds, it was confirmed that the consumption of a complex such as rosemary extract (SunMax) improved the formation of wrinkles in four areas of the face [1].
"As a result of taking rosemary extract complex (225 mg/day) for 13 weeks, there was a significant decrease in wrinkle formation (eyebrows, nasolabial folds, marionette wrinkles, wrinkles around the mouth), visual evaluation by dermatologist (erythema, itching), and subjective skin evaluation (facial wrinkles) compared to the control group."
As mentioned earlier, the main cause of exogenous aging is ultraviolet radiation. The word 'photoaging', which refers to skin aging caused by ultraviolet rays, is used interchangeably with 'exogenous aging'. When exposed to ultraviolet rays, free radicals increase and collagen and elastin degradation enzymes are expressed. As a result, the elasticity of the skin decreases and wrinkles occur.
In 2002, it was reported in the academic community that Carnosic Acid, one of the key components of SunMax complex, inhibits the expression of ultraviolet ray-induced collagenase (MMP-1) in human fibroblasts [2].
Ultraviolet rays not only cause skin aging by breaking down collagen and elastin, but also increase free radicals to produce various pro-inflammatory cytokines, which promote cell necrosis and natural cell death. As a result, not only skin elasticity but also the condition of the skin as a whole decreases.
The reason why the rosemary extract and other compounds (SunMax), which inhibit the expression of collagenase by ultraviolet rays, are special is that they can also be expected to have anti-inflammatory effects. A 2012 study confirmed the anti-inflammatory benefits of a composition of carnosic acid and lutein, which are key components of rosemary extract and other compounds (SunMax) [3].
"The composition of lutein and carnose acid showed a significant level of synergistic inhibition (80%) of the activity of NF-kB. These results indicate a significant synergy between the two components."
Today, we looked at an ingredient that can be called the strongest exogenous anti-aging from wrinkle formation to prevention of photoaging, and a complex (SunMax) such as rosemary extract. Many people are taking collagen and elastin for anti-aging, but if you pay attention to preventing the destruction caused by ultraviolet rays as much as you take care of the components of the dermis that are decreasing due to aging, you will be able to prevent skin aging more efficiently.
I hope you have a healthy day in body and mind. It was Jinny.
[1] Ministry of Food and Drug Safety, Consumer Report on Functional Ingredients for Health Functional Foods (draft) – Rosemary Extract Complex [No. 2021-18]
[2] Offord, E. A., Gautier, J. C., Avanti, O., Scaletta, C., Runge, F., Krämer, K., & Applegate, L. A. (2002). Photoprotective potential of lycopene, β-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radical Biology and Medicine, 32(12), 1293-1303.
[3] Hadad, N., & Levy, R. (2012). The synergistic anti-inflammatory effects of lycopene, lutein, β-carotene, and carnosic acid combinations via redox-based inhibition of NF-κB signaling. Free Radical Biology and Medicine, 53(7), 1381-1391.
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