[Effects of Siberian Chrysanthemum] 3 Benefits of Siberian Chrysanthemum for Relieving Joint Pain

Hello, I am Jinny, a pharmacist.

The reason arthritis is so painful is because of pain Joint pain can be more excruciating than other types of pain. It continues even during sleep and can significantly impact your quality of life.

If you've been dealing with such excruciating joint pain, you should pay attention to "Siberian Chrysanthemum." Derived from its meaning "a herb that bends on September 9th of the lunar calendar," Siberian Chrysanthemum is known for its benefits for joint health and is sometimes referred to as "joint chrysanthemum."

The reason Siberian Chrysanthemum can offer joint-related benefits is thanks to a compound called 'linalin,' which is a type of flavonoid. Research has shown that linalin can suppress inflammation in the joints and deactivate factors that cause damage to cartilage tissue[1].
[1] Wang, Junsheng; Fu, Bin; Lu, Fuchun; Hu, Xiaowu; Tang, Jinshan; Huang, Lixin (2017). Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway. Biochemical and Biophysical Research Communications, 495(3). 2133-2138.

Siberian Chrysanthemum, which is rich in linalin, has recently been recognized as an ingredient for dietary supplements by the U.S. FDA. Now, let's explore how Siberian Chrysanthemum affects joint pain through researches with human trials and animal experiments.

Did you know that joint pain can lead to depression? Chronic pain not only causes a sense of sadness but also various psychological responses, including feelings of helplessness, anxiety, and anger. There is even research indicating that patients with joint pain have a 20% increased risk of depression[2]. Joint pain is undeniably challenging both physically and mentally.
[2] Gandhi, Rajiv; Zywiel, Michael G.; Mahomed, Nizar N.; Perruccio, Anthony V. (2015). Depression and the Overall Burden of Painful Joints: An Examination among Individuals Undergoing Hip and Knee Replacement for Osteoarthritis. Arthritis, 1–6.

In relation to this, human trials confirming the pain-relief effects of Siberian Chrysanthemum found that when Siberian Chrysanthemum extract at a dose of 250mg/day was consumed for 12 weeks, VAS* pain scores significantly decreased.
*VAS (Visual Analogue Scale): A numerical score that quantifies the intensity of pain or symptoms as perceived by the patient themselves.

As I mentioned earlier, joint pain caused by arthritis can have a significant impact on one's overall quality of life, even leading to depression. Siberian Chrysanthemum has a clinical evidence that it not only relieves joint pain but also improves the joint health and quality of life for patients with osteoarthritis.

In 2021, a clinical trial was conducted on 121 patients with knee osteoarthritis to study the efficacy of Siberian Chrysanthemum extract. After 12 weeks of taking 250mg/day of GCWB106 (Siberian Chrysanthemum extract), significant improvements were observed in pain scores and key indicators related to the quality of life, as measured by the KSF-36 scores, when compared to the placebo group at 6 and 12 weeks.

Arthritis can be broadly categorized into two types: degenerative arthritis and rheumatoid arthritis. Degenerative arthritis, which typically occurs in individuals aged 45 and above, is closely associated with aging. On the other hand, rheumatoid arthritis is an autoimmune disease that can affect even younger individuals, where the immune system attacks the joints, causing pain, swelling, and deformities.

One of the known causes of rheumatoid arthritis is the activation of osteoclast cells within the joints, which leads to bone destruction[3]. Therefore, finding factors that inhibit osteoclast cell differentiation is considered crucial in the treatment of rheumatoid arthritis.
[3] Lee, Sang-Heon (2011). Osteoclastogenesis in Rheumatoid Arthritis. Journal of Rheumatic Diseases, 18(2), 71.

Studies have confirmed that Siberian Chrysanthemum (Siberian Chrysanthemum extract) can help inhibit osteoclast cell differentiation and prevent rheumatoid arthritis through animal experiments.

So far, we have explored the benefits of consuming Siberian Chrysanthemum extract through research. Siberian Chrysanthemum extract is generally considered a safe ingredient; however, individuals with specific allergies should be cautious when consuming it. It is recommended to adhere to the daily recommended intake of 250mg.

Moreover, if you have been diagnosed with arthritis, it is important to consume ingredients that are good for your joints, but the most essential thing is regular exercise. Adequate exercise helps strengthen muscles and improve bone and joint function. Therefore, experts often recommend engaging in moderate-intensity aerobic or strength exercises for at least 30 minutes a day.

However, if arthritis is severe, it's best to avoid activities such as hiking, running, or jumping, as they can put excessive strain on the joints. Climbing stairs or uphill walking can be beneficial, but the downward movements can be hard on the joints.

I hope you have a healthy day both physically and mentally. This was Jinny.