[ParActin(R)] from joint pain to fever · Until pain, 3 benefits of natural anti-inflammatory Tianxiang Lotus Extract

Rheumatoid arthritis, which is the second most common chronic arthritis after osteoarthritis and the most common cause of inflammatory arthritis, is also a significant pain and can be used with large doses of anti-inflammatory drugs. It is a major disease that causes long-term use. Rheumatoid arthritis is a chronic inflammatory disease characterized by a persistent inflammatory response of the synovial membrane of the joint, and it is known that in 50% of patients who develop it, they will have impairment of daily living as the disease progresses [4].

Despite the fact that it is a serious disease that can reduce the patient's quality of life and cause social and economic losses due to pain, fatigue, and depressive symptoms, there is no single treatment that can be applied to all patients with rheumatoid arthritis, and there is no method of prevention or cure, so treatment is generally aimed at reducing pain and maintaining physical function [5].

In the case of ParActin®, the benefits for rheumatoid arthritis were reported earlier than the benefits for osteoarthritis. As early as 2009, Burgos, R. A, et al., et al., in a clinical trial involving 60 patients with rheumatoid arthritis, reported significant symptom improvement following the supplementation of ParActin®, and Li, X., Yuan, et al. (2019) elucidate the mechanism by which ParActin® improves rheumatoid arthritis [7].

"This study investigated the anti-arthritic mechanism of sacralia extract in a rheumatoid arthritis induction model, and our results show that it alleviates arthritis by promoting neutrophil cell death and inhibits autophagy-dependent NETosis of neutrophils. These findings suggest that it has significant pharmaceutical potential for the treatment of rheumatoid arthritis."

As explained above, ParActin® is an ingredient that may provide significant benefits for both osteoarthritis and rheumatoid arthritis. For this reason, the Korean Ministry of Food and Drug Safety recognizes this ingredient as a functional ingredient for joint health. However, the reason why I describe it as a 'natural analgesic anti-inflammatory' is because ParActin® is a great source of analgesia in inflammatory diseases. In addition to its anti-inflammatory benefits, it also has an effect on fever.

One of the first potential benefits of paractin® is antipyretic and antipyretic. As early as 1991, Thamlikitkul, V. et al. and colleagues conducted a clinical trial on 152 patients with pharyngeal tonsillitis [8] and Madav, S. and colleagues (1995) confirmed significant antipyretic and analgesic activity after 3 hours of ingestion of paractinus extract [9].

"Consumption of Tianxiang Chinensis extract showed significant (P<0.05) analgesic activity and significant (P<0.05) antipyretic effect 3 hours after administration in a fever-inducing model. In addition, aspirin induced ulcers in rats, whereas celestial heart extract showed significant (p<0.05) anti-ulcer activity."

Today, we took a look at ParActin®, which is worthy of the name of 'natural anti-inflammatory analgesic'. Similar to nonsteroidal anti-inflammatory drugs (NSAIDs) consumed as medicines, they appear to be effective against fever and pain, as well as inflammation. It has clinical studies on improving arthritis as well as respiratory infections, including sinusitis and the common cold, [10] so its use is in line with common anti-inflammatory drugs.

Furthermore, depending on the type, liver · Gastrointestinal system · Elongation · Unlike anti-inflammatory drugs, which can cause cardiovascular side effects, anti-ulcer · Improved blood circulation · Benefits of improving cardiovascular function [11] have also been reported, suggesting that it can be taken relatively safely and long-term.

However, in the case of ParActin, it is recommended that adolescents under the age of 18, pregnant and lactating women, and those planning to become pregnant should avoid taking ParActin®, according to animal clinical reports [12] that it has a contraceptive effect.

I hope you have a healthy day in body and mind. It was Jinny.

[1] Korea Disease Control and Prevention Agency's National Health Information Portal, Health Information <Osteoarthritis>
[2] Yu, G., Xiang, W., Zhang, T., Zeng, L., Yang, K., & Li, J. (2020). Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complementary Medicine and Therapies, 20(1), 1-16.
[3] Hancke, J. L., Srivastav, S., Cáceres, D. D., & Burgos, R. A. (2019). A double‐blind, randomized, placebo‐controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. Phytotherapy Research, 33(5), 1469-1479.
[4,5] Centers for Disease Control and Prevention National Health Information Portal, Health Information <Rheumatoid Arthritis>
[6] Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., & Cáceres, D. D. (2009). Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clinical rheumatology, 28(8), 931-946.
[7] Li, X., Yuan, K., Zhu, Q., Lu, Q., Jiang, H., Zhu, M., ... & Xu, A. (2019). Andrographolide ameliorates rheumatoid arthritis by regulating the apoptosis–NETosis balance of neutrophils. International journal of molecular sciences, 20(20), 5035.
[8] Thamlikitkul, V., Dechatiwongse, T., Theerapong, S., Chantrakul, C., Boonroj, P., Punkrut, W., ... & Petcharoen, S. (1991). Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. Journal of the Medical Association of Thailand= Chotmaihet thangphaet, 74(10), 437-442.
[9] Madav, S., Tripathi, H. C., & Mishra, S. K. (1995). Analgesic, antipyretic and antiulcerogenic effects of andrographolide. Indian Journal of Pharmaceutical Sciences, 57(3), 121.
[10,11,12] ayakumar, T., Hsieh, C. Y., Lee, J. J., & Sheu, J. R. (2013). Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent andrographolide. Evidence-Based Complementary and Alternative Medicine, 2013.