[Effects of ParActinⓇ] From Joint Pain to Overall Pain Relief,  3 Benefits of Natural Anti-inflammatory Agent ParActinⓇ

[Effects of ParActinⓇ] From Joint Pain to Overall Pain Relief, 3 Benefits of Natural Anti-inflammatory Agent ParActinⓇ

Dec 03, 2023KimSunhyo

[Effects of ParActinⓇ] From Joint Pain to Overall Pain Relief, 3 Benefits of Natural Anti-inflammatory Agent ParActinⓇ

A Natural Anti-inflammatory Pain Reliever, ParActinⓇ
This content is health information about ingredients and not directly related to a specific product.
Recommended to
1. Those suffering from arthritis but unable to prescribe anti-inflammatory painkillers due to underlying disease
2. Those who are concerned about the pain worsening if they do not take anti-inflammatory painkillers because the effects of anti-inflammatory painkillers are short.
3. Those who have difficulty taking anti-inflammatory painkillers due to side effects
Effects of ParActinⓇ
1. Improves Pain and Symptoms of Osteoarthritis
2. Improves Rheumatoid Arthritis
3. Anti-inflammatory and Relieves Pain

Hello, I am Jinny, a pharmacist.

Do you all remember the advertising copy, “OOLin for headaches, toothaches, and menstrual cramps”? ‘OO Lenol’, which caused a shortage during the peak of the coronavirus infection epidemic, is also a very familiar product to us. As such, the medicines we take most often and easily in our daily lives are by far anti-inflammatory painkillers.

It is used for a variety of symptoms, including cold body aches, arthritis, back pain, muscle pain, and headaches, so it is a commonly taken medicine by patients from young children to the elderly. Particularly, since the main ingredient in arthritis medications are anti-inflammatory painkillers, many seniors who take prescription medications for joint problems may be taking two or more types of anti-inflammatory painkillers for a long period of time.

Because they are commonly taken for a long period of time, anti-inflammatory painkillers are also a group of medicines with many side effects. Acetaminophen, the main ingredient in 'OO Lenol', has the side effect of liver toxicity, and non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen have gastritis, gastric ulcer, gastric bleeding, and kidney side effects, and even may increase the risk of cardiovascular disease.

However, many people are experiencing side effects from anti-inflammatory painkillers but are unable to stop taking them due to chronic pain. Today, I would like to introduce you to an ingredient that can be helpful to these people. ParActin® is a functional ingredient for joint health recognized by the Ministry of Food and Drug Safety and a natural analgesic and anti-inflammatory agent traditionally used to treat infections.

1. Improves Pain and Symptoms of Osteoarthritis

As mentioned earlier, the most common cause of taking anti-inflammatory painkillers in large quantities and for a long period of time is arthritis. Especially, osteoarthritis, also called degenerative arthritis, occurs with a frequency of more than 60% in people over 65 years of age [1]. It is an inflammatory joint disease that damages joint cartilage. It is known to initially cause local pain in the inflamed joint, but as the disease progresses, persistent pain occurs regardless of movement.

Since there is currently no definite drug that can prevent or treat osteoarthritis, the most common treatment for osteoarthritis is through non-steroidal anti-inflammatory drugs (NSAIDs). However, non-steroidal anti-inflammatory drugs not only have the risk of pharmacological side effects, but also interfere with the synthesis of glycosaminoglycans that make up skin tissue and cartilage due to their mechanism, so they are not effective in restoring or treating cartilage degenerated by osteoarthritis.

For this reason, research is continuously being conducted in academia to find effective alternatives, and the ingredient that has recently produced significant results is ParActin®. In 2019, Hancke, J. L. and researchers reported that a significant pain reduction was confirmed following the consumption of ParActin® in a human application test targeting 103 osteoarthritis patients.
[1] Korea Disease Control and Prevention Agency National Health Information Portal, health information
[2] Yu, G., Xiang, W., Zhang, T., Zeng, L., Yang, K., & Li, J. (2020). Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complementary Medicine and Therapies, 20(1), 1-16.

"From 28 days of ingestion of ParActin®, there was a significant improvement in pain compared to the placebo group, and significant improvements were also seen in joint stiffness, physical function, and fatigue. ... Overall, ParActin® showed significant improvement in joint stiffness, physical function, and fatigue. “It can be concluded that both 300 mg/day and 600 mg/day are effective and safe in reducing pain in individuals with mild to moderate osteoarthritis.”

Reference :  Hancke, J. L., Srivastav, S., Cáceres, D. D., & Burgos, R. A. (2019). A double‐blind, randomized, placebo‐controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. Phytotherapy Research, 33(5), 1469-1479..
2. Improves Rheumatoid Arthritis

Rheumatoid arthritis, the second most common disease among chronic arthritis after osteoarthritis and the most common cause of inflammatory arthritis, is also a major disease that causes significant pain and causes the use of large amounts and long-term anti-inflammatory painkillers. Rheumatoid arthritis is a chronic inflammatory disease characterized by a continuous inflammatory response in the joint synovium, and 50% of affected patients are known to experience impairment in daily life as the disease progresses [3].

Although it is a serious disease that can reduce the patient's quality of life and cause social and economic losses due to pain, fatigue, and depressive symptoms, there is currently no single treatment that can be applied to all rheumatoid arthritis patients, and there is no prevention or cure. Thus, treatment is generally aimed at relieving pain and maintaining physical function [4].

In the case of ParActin®, it is an ingredient whose benefits for rheumatoid arthritis were reported first rather than for osteoarthritis. In 2009, Burgos, R. A, and researchers reported significant symptom improvement following the consumption of ParActin® in a human application test targeting 60 rheumatoid arthritis patients [5], Li, X., Yuan, and researchers (2019) also revealed the mechanism of improving rheumatoid arthritis by ParActin®.
[3,4] Korea Disease Control and Prevention Agency National Health Information Portal, health information
[5] Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., & Cáceres, D. D. (2009). Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clinical rheumatology, 28(8), 931-946.

"This study investigated the anti-arthritis mechanism of Cheonchimryun extract in a rheumatoid arthritis-induced model. Our results show that Cheonchimryun extract alleviates arthritis by promoting neutrophil apoptosis and inhibits autophagy-dependent NETosis of neutrophils. “These findings suggest that Chrysanthemum lily extract has significant pharmaceutical potential for the treatment of rheumatoid arthritis.”

Reference :  Li, X., Yuan, K., Zhu, Q., Lu, Q., Jiang, H., Zhu, M., ... & Xu, A. (2019). Andrographolide ameliorates rheumatoid arthritis by regulating the apoptosis–NETosis balance of neutrophils. International journal of molecular sciences, 20(20), 5035.
3. Anti-inflammatory and Relieves Pain

As explained above, ParActin® is an ingredient that can provide significant benefits for both osteoarthritis and rheumatoid arthritis. For this reason, our Ministry of Food and Drug Safety recognizes this ingredient as a functional ingredient for joint health. However, the reason I describe this ingredient as a ‘natural pain-relieving and anti-inflammatory agent’ is because ParActin® has pain-relieving and anti-inflammatory benefits in inflammatory diseases and is also effective in treating fever.

Among the potential benefits of ParActin®, the first to be studied was its antipyretic and analgesic effect. In 1991, Thamlikitkul, V. and researchers conducted a human application test on 152 pharyngotonsillitis patients. [6] Madav, S. and researchers (1995) confirmed significant antipyretic and analgesic activity 3 hours after ingestion of ParActin®.

"Ingestion of Cheonsimnyeon extract showed significant (P<0.05) analgesic activity and significant (P<0.05) antipyretic effect 3 hours after administration in a fever-inducing model. In addition, while aspirin caused ulcers in rats, , Cheonsimnyeon extract showed significant

Reference :  Madav, S., Tripathi, H. C., & Mishra, S. K. (1995). Analgesic, antipyretic and antiulcerogenic effects of andrographolide. Indian Journal of Pharmaceutical Sciences, 57(3), 121.

Today, we looked at ParActin®, which is worthy of being called a ‘natural anti-inflammatory painkiller.’ Similar to non-steroidal anti-inflammatory drugs (NSAIDs) consumed as medicines, it appears to be effective against inflammation as well as fever and pain. There are also clinical studies on improving respiratory infections, including arthritis, sinusitis, and colds [7], so its use can be said to be in line with general anti-inflammatory painkillers.

Furthermore, unlike anti-inflammatory analgesics, which can cause side effects in the liver, gastrointestinal system, kidneys, and cardiovascular system depending on the type, other advantages such as, the benefits of anti-ulcer, improved blood circulation, and cardiovascular function have also been reported [8], meaning that they can be taken relatively safely for a long period of time.

However, according to animal clinical reports that it has a contraceptive effect [9], the Ministry of Food and Drug Safety advises adolescents under 18 years of age, pregnant and lactating women, and those planning to become pregnant to avoid consumption. It would be advisable to take this into consideration when consuming it.

I hope you have a healthy day both physically and mentally. This was Jinny.
[7-9] Jayakumar, T., Hsieh, C. Y., Lee, J. J., & Sheu, J. R. (2013). Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent andrographolide. Evidence-Based Complementary and Alternative Medicine, 2013.

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