[Effects of Choline] Essential for Brain Function? 3 Reasons Academia Is Paying Attention to Choline
Nov 19, 2023KimSunhyo
[Effects of Choline] Essential for Brain Function?
3 Reasons Academia Is Paying Attention to Choline
Essential for Brain Function? What is Choline?
This content is health information about ingredients and not directly related to a specific product.
Effects of Choline
1. Improves Language Memory 2. Enhances Information Processing Speed in Children 3. Assists Weight Reduction
Hello, I am Jinny, a pharmacist.
Have you ever heard of "choline"? If you're someone who takes supplements like 'acetylcholine,' which is often referred to as a brain function or dementia supplement, you might have an idea.
Choline is one of the B-complex vitamins and is synthesized in the body as acetylcholine. Acetylcholine contributes to regulating learning and memory in the central nervous system. Moreover, choline is used in the synthesis of phospholipids, which are components of cell membranes, and it also plays a role in transporting accumulated fat out of the liver.
Now, let's take a look at various benefits of choline that have been validated by academia.
1. Improves Language Memory
As we age, it's natural for cognitive functions such as reasoning, spatial perception, and language abilities to decline. Sometimes, during conversations, we may struggle to recall words, which can be frustrating. Choline is the precursor to acetylcholine, which is known to support memory and learning abilities. Therefore, choline can have a positive impact on brain metabolism mediated by acetylcholine.
In this context, a study published in the Archives of Neurology in 1996 reported that older individuals with lower language memory compared to their peers showed improved language memory when they consumed choline.
"Overall, this study demonstrated that citicoline (a source of choline) enhances language memory in older participants with lower performance compared to their peers."
Reference : Spiers, P. A., Myers, D., Hochanadel, G. S., Lieberman, H. R., & Wurtman, R. J. (1996). Citicoline improves verbal memory in aging. Archives of neurology, 53(5), 441–448.
2. Enhances Information Processing Speed in Children
Choline promotes fetal and placental tissue expansion, DNA methylation, and other processes during fetal development. Additionally, it helps in the formation of phosphatidylcholine, a major component of cell membranes necessary for signal transmission, brain development, and fetal growth.
A paper published in the FASEB Journal in 2018 reported that infants born to mothers who supplemented with choline from the third trimester of pregnancy until birth had faster information processing speed. The study suggested that this result was due to the increased availability of choline-derived membrane lipids, which improved nerve conduction velocity.
The average reaction time (RT) over four ages (4, 7, 10, and 13 months) was significantly faster in infants born to mothers in the choline 930mg group. This result indicates that consuming approximately twice the recommended amount of choline during late pregnancy enhances information processing speed in infants.
Reference : Caudill, M. A., Strupp, B. J., Muscalu, L., Nevins, J., & Canfield, R. L. (2018). Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(4), 2172–2180.
3. Assists Weight Reduction
Choline plays a role in fat metabolism, making it a useful substance in preventing conditions like fatty liver or excessive fat levels in the blood. Additionally, efficient fat metabolism with choline is associated with a higher level of satiety, which can help with overall weight loss.
In relation to this, a study published in the Journal of Human Kinetics in 2014 investigated the relationship between choline supplementation and body mass.
"In conclusion, choline supplementation can lead to a rapid reduction in body mass without any side effects on biochemical levels or static strength."
Reference : Elsawy, G., Abdelrahman, O., & Hamza, A. (2014). Effect of choline supplementation on rapid weight loss and biochemical variables among female taekwondo and judo athletes. Journal of human kinetics, 40, 77–82.
Today, we have explored various benefits associated with choline supplementation through research papers. Choline is an essential nutrient that is not synthesized significantly within the body and must be supplemented through food or dietary sources. However, it's important to note that consuming more than 3.5 grams of choline per day can lead to side effects such as diarrhea or vomiting, so caution is advised.
I hope you have a healthy day both physically and mentally. This was Jinny.