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Hello. I'm a pharmacist Jinny.
Diet really seems to be everyone's concern. That's why every year, every month, there are new diet supplements. Today, I would like to introduce you to the very popular "Cissus Diet", which is called the "magic powder".
Cissus is a plant belonging to the grape family and has been used for a long time in Ayurvedic medicine, a traditional Indian medicine, known for its antioxidant, anti-inflammatory, and antimicrobial properties. In recent years, it has been shown that due to the action of various flavonoids in cissus, it has an anti-obesity effect.
As a result, in 2018, the Korean Ministry of Food and Drug Safety also recognized the function of cissus extract to reduce body fat, and it is gaining popularity as a diet supplement in Korea. In fact, people who have tried the Cissus diet have said that their waist circumference has decreased, and they have lost weight easily, which has become even more topical.
So, what about the real-world effects that have been proven in the study? Let's take a look.
Did you know? Even with the same obesity, the risk of various obesity complications increases as the waist circumference increases. In other words, abdominal obesity is especially dangerous than gaining weight in other parts of the body.
Here are the results of a human application test published in 2019. In this study, cissus extract, which is made from the leaves and stems of Cissus, was given to overweight subjects at a dose of 300 mg daily.
After 8 weeks, there was a significant reduction in body weight and body fat, as well as waist circumference, compared to the placebo group [1].
"After 8 weeks of treatment, participants in the placebo group experienced a 1.05% reduction in body fat determined by bioelectrical impedance analysis, but there was no difference when using DEXA. During the same period, the Cissus extract group lost 8.9% and 12.8% of body fat measured by impedance and DEXA, respectively. This value was significantly lower than placebo. Compared to placebo, the Cissus extract group showed significant reductions in waist and hip circumference, systolic and diastolic blood pressure, total cholesterol, triglycerides, fasting blood glucose, and leptin levels."
Some people may be worried because they can't lose weight well even though they manage their diet and exercise. This may be due to a hormonal imbalance.
In our body, several hormones interact to regulate our weight. One example is adiponectin. Adiponectin is a type of hormone secreted by fat cells, and it is a "good hormone" that inhibits the synthesis of fat and promotes burning.
In the aforementioned study, it was demonstrated that the consumption of cissus extract significantly increased serum adiponectin levels [2].
"Serum leptin levels decreased significantly in the Cissus extract group, while adiponectin levels increased significantly."
In addition to obesity, diabetes is also a major adult disease. Prolonged hyperglycemia due to diabetes increases oxidative stress and inflammation caused by free radicals. And because of this, all kinds of diabetic complications arise. So, if you've been diagnosed with diabetes, you need to take extra care to manage your blood sugar.
Cissus is not only anti-obesity, but also has anti-diabetic activity, and a lot of research is being done. In areas where cissus has been cultivated since ancient times, it is said that cissus has been used to treat diabetes.
Scientific observers speculate that the anti-diabetic activity of Cissus may be due to the various bioactive substances it contains, which reduce blood sugar and perform antioxidant and anti-inflammatory effects [3].
"Our study clearly showed that Cissus stems have potent antioxidant and anti-inflammatory activity in STZ/nicotinamide-induced diabetic rats. Cissus stems exert their activity by up-regulating antioxidant status and down-regulating inflammatory pathways. The beneficial effects of cissus stems were comparable to the antidiabetic drug metformin. The phenolic compounds present in cissus stems may act as potential candidates for delaying the progression of diabetic complications. Therefore, dietary supplementation of cissus stem may be beneficial in the management of diabetes complications and may be developed as a new food additive or drug ingredient for the prevention of diabetes."
Today, we're going to talk about the effects of the Cissus diet. In clinical trials, Cissus has been shown to reduce weight, body fat, and waist circumference, as well as improve levels of adiponectin, a fat-burning hormone. It is also actively researched for its anti-diabetic activity.
However, cissus extract, which has been recognized for its ability to reduce body fat, is an ingredient that has been reviewed for safety by the Ministry of Food and Drug Safety, but as we have seen, it has the effect of lowering blood sugar, so if you are taking a blood sugar-lowering drug, you should be careful about consuming it.
So, I hope you have a healthy day in body and mind. It was Jinny.
[1,2] Nash, R., Azantsa, B., Kuate, D., Singh, H., & Oben, J. (2019). The Use of a Stem and Leaf Aqueous Extract of Cissus quadrangularis (CQR-300) to Reduce Body Fat and Other Components of Metabolic Syndrome in Overweight Participants. Journal of alternative and complementary medicine (New York, N.Y.), 25(1), 98–106.
[3] Lekshmi, R. K., Rajesh, R., & Mini, S. (2015). Ethyl acetate fraction of Cissus quadrangularis stem ameliorates hyperglycaemia-mediated oxidative stress and suppresses inflammatory response in nicotinamide/streptozotocin induced type 2 diabetic rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 22(10), 952–960.
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