joint pain2. Improves joint health and quality of life in patients with osteoarthritis
Hello. I'm a pharmacist Jinny.
The reason why arthritis is painful is because of the pain. Joint pain is said to be more painful than colic. It continues until you fall asleep and reduces your quality of life.
If you have been suffering from such painful joint pain, you should pay attention to 'Gugu Herb'. Derived from the meaning of grass that breaks on the 9th day of the 9th month of the lunar calendar, it is known as a medicinal herb that helps joints, and is also called "joint herb".
The reason why it can have joint-related benefits is because of a substance called linin, which is a type of flavonoid. Linarin has been shown to inhibit inflammation in joints and inactivate cartilage tissue cell destruction factors [1].
Recently, the US FDA has listed it as a health food. Now, let's take a look at how it affects joint pain through human trials and animal studies related to it.
Did you know that joint pain can even lead to depression? Chronic pain is said to cause a variety of psychological reactions, including feelings of helplessness, anxiety, and anger, as well as depression. Studies have shown that patients with joint pain have a 20% increased risk of depression [2]. Joint pain is physically and mentally exhausting.
In this regard, in a clinical trial that demonstrated the pain-improving effect of this herb, it was found that the consumption of 250 mg/day of the extract for 12 weeks significantly reduced the VAS* pain score [3].
"The GCWB106 group showed a greater reduction in VAS pain scores compared to the placebo group."
As I mentioned earlier, arthritis pain affects all aspects of life, even causing depression. In addition to arthritis pain, it has been shown to improve joint health and quality of life in patients with osteoarthritis.
In 2021, the results of a clinical trial on 121 patients with knee arthritis were published on the efficacy of this extract. When 121 patients with arthritis were given 250 mg/day of GCWB106 for 12 weeks, there was a significant improvement in the KSF-36 score, a marker related to pain scores and quality of life, compared to the placebo group.[4].
"GCWB106 demonstrates a better ability to reduce pain and improve physical function, quality of life, and joint health in patients with early arthritis."
Arthritis is broadly divided into degenerative arthritis and rheumatoid arthritis. Degenerative arthritis, which occurs in people over the age of 45, is closely related to aging, while rheumatoid arthritis is an autoimmune disease that occurs in young people and causes pain, swelling, and deformity when the immune system attacks the joints.
One of the causes of rheumatoid arthritis is known to be the activation of osteoclasts, which destroy bone in the joints [5]. Therefore, it is important to look for inhibitory factors related to osteoclast differentiation in the treatment of rheumatoid arthritis.
Studies have shown in animal studies that it can help inhibit osteoclast differentiation and prevent rheumatoid arthritis [6]
"Glycyrrhis extract has been shown to inhibit the differentiation of osteoclasts and prevent rheumatoid arthritis."
So far, we've looked at the benefits of consuming this herb through research. Although it is generally a safe ingredient, those with certain allergies should be cautious about consuming it and recommend that they stick to the recommended daily intake of 250mg.
Also, if you've been diagnosed with arthritis, it's important to make sure you're getting the best ingredients for your joints, but the most important thing is to exercise regularly.
This is because proper exercise strengthens muscles and helps improve bone and joint function. For this reason, specialists recommend doing at least 30 minutes of moderate-intensity aerobic or strength training per day.
However, if you have severe arthritis, it is best to avoid exercises such as hiking, running, or jumping, as they can be toxic to your joints. Climbing stairs or mountains is great, but going down can put a lot of strain on your joints.
So, I hope you have a healthy day in body and mind. It was Jinny.
[1] Wang, Junsheng; Fu, Bin; Lu, Fuchun; Hu, Xiaowu; Tang, Jinshan; Huang, Lixin (2017). Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway. Biochemical and Biophysical Research Communications, 495(3). 2133-2138.
[2] Gandhi, Rajiv; Zywiel, Michael G.; Mahomed, Nizar N.; Perruccio, Anthony V. (2015). Depression and the Overall Burden of Painful Joints: An Examination among Individuals Undergoing Hip and Knee Replacement for Osteoarthritis. Arthritis, 1–6.
[3] Lee, T., Na, C. B., Kim, D., Han, H. J., Yun, J., Park, S. K., & Cho, E. (2023). Osteoarthritis improvement effect of Chrysanthemum zawadskii var. latilobum extract in relation to genotype. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 93(5), 410–419.
[4] Ha JK, Kim JS, Kim JY, Yun JB, Kim YY, Chung KS. (2021). Efficacy of GCWB106 (Chrysanthemum zawadskii var. latilobum extract) in osteoarthritis of the knee: A 12-week randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 100(26):e26542.
[5] Lee, Sang-Heon (2011). Osteoclastogenesis in Rheumatoid Arthritis. Journal of Rheumatic Diseases, 18(2), 71.
[6] Hong, Jeong-Min; Shin, Jun-Kyu; Kim, Jeom-Yong; Jang, Min-Jung; Park, Sun-Kyu; Lee, Jong-Hoon; Choi, Jung-Hyo; Lee, Sun-Mee (2018). BST106 protects against cartilage damage by inhibition of apoptosis and enhancement of autophagy in osteoarthritic rats. Biological and Pharmaceutical Bulletin, 41(8), 1257-1268.
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