2. Reduction of abdominal fat, visceral fat, and subcutaneous fat
Hello. I'm a pharmacist Jinny.
It's autumn, the season of heaven and earth that has come again this year. In fact, it is said that in autumn, the amount of sunlight decreases, which leads to a decrease in the secretion of serotonin, which increases appetite and the desire to eat carbohydrates. In addition, as the temperature drops, our body tries to accumulate subcutaneous fat. It is true that these changes, which last from autumn to early spring, are not always welcome.
Today, I would like to introduce you to cutting-edge diet ingredients that can be consumed in the long term from autumn to spring, when it is easy to gain weight, and manage body fat. It's Morosil®, a plant-based diet ingredient derived from Moro oranges from Sicily's Etna volcanic region. Morosil, which contains C3G, a type of anthocyanin abundant in Moro orange, has not only been recognized by the Ministry of Food and Drug Safety for its ability to reduce body fat, but it has also been confirmed to improve seven indicators related to diet according to its intake in human body application tests.®
In addition, Morosil® is an ingredient with very few side effects from ingestion. In the case of Garcinia Cambogia Extract, a representative functional ingredient in the diet, it is necessary to be careful about the intake of the drug if you have liver, kidney, or heart disease, and in the case of catechin, a well-known dietary functional ingredient, you should be careful not only about the intake of liver disease, but also be careful about the intake of caffeine during the intake of the ingredient. Morosil®, on the other hand, is a unique dietary functional ingredient with no specific dietary precautions. Let's take a closer look at the benefits of these safe and reliable new diet ingredients.
In the past, many people focused on weight (kg) when dieting, but nowadays, the main purpose of dieting is to maintain a healthy and balanced body line by paying attention to BMI and the 'eye body' that can be seen with the naked eye, along with weight. As a result, when evaluating the benefits of dietary functional ingredients, whether they can contribute to the 'eye body' beyond weight loss has emerged as a key evaluation factor.
In 2018, Medical treatment and new medicine reported the results of a clinical trial evaluating the benefits of morosil® supplementation in 60 adults with a BMI of 27 who were not obese. This study reported that 12 weeks of intake of 400 mg/day of Morosil® resulted in a reduction in body weight and BMI, as well as a reduction in waist circumference of approximately 7 cm and hip circumference of approximately 6 cm [1].
"In conclusion, we found that 12 weeks of Morosil® intake was associated with weight loss, improved BMI, and reduced waist and hip circumference, even in non-obese individuals. In addition, there were no safety concerns during the 12-week trial period."
Unlike diets that are meant to satisfy individual subjective aesthetic preferences and desires for self-expression, there are also diets that are essential for the health of our body. In particular, visceral fat, which accumulates in the abdominal cavity and around the intestines, can increase the risk of cardiovascular disease and diabetes due to metabolic syndrome, hyperlipidemia, and insulin resistance if the amount is increased.
As the management of visceral fat is highly important for maintaining health, it has become a major issue for the academic community to consider whether Morosil®, which has begun to be known as a new material in diets, can contribute to the management of visceral fat, and a human application test published in Nutrients in 2022 reported that the consumption of Morosil® improved BMI, waist and hip circumference, as well as abdominal fat, visceral fat, and subcutaneous fat [2].
"Both fat mass and fat distribution (visceral fat and subcutaneous fat) were significantly improved in the Morosil® group compared to the placebo group. In addition, all safety indicators related to hepatotoxicity did not deviate from normal ranges throughout the study."
How does Morosil®, which has been shown to have various benefits related to dieting in human trials, work? A research report published in Natural Product Research in 2021 revealed the mechanism of Morosil® in reducing body fat as anti-fat production activity based on antioxidant activity.
Adipogenesis refers to the process by which fatty cells, or fat cells, develop and accumulate into adipose tissue in various parts of the body. If you continue to consume more energy than you consume, tissue fat cells not only multiply in number, but also increase in size. This study explains the mechanism by which Morosil® inhibits this process of lipogenesis [3].
"The results of this study show that Morosil® exerts antioxidant and anti-lipanogenic activity during adipocyte differentiation of adipocytes in adipocytes."
Today, we looked at the benefits of taking Morosil®, a cutting-edge diet material obtained from the Etna volcanic field in Sicily, and the mechanism of fat loss. Many studies suggest that it can be consumed not only for dieting but also for the prevention of overweight and obesity, so it would be a good idea to use it in the fall and winter, when body fat tends to increase like getting wet in the drizzle.
I hope you have a healthy day in body and mind. It was Jinny.
[1] Kaneko, T., & Shikarawa, T. A. (2018). Study on Supplement Containing Moro (Citrus Sinensis (L.) Osbeck) Orange Extract of a Randomized Placebo-controlled Trial Part 2: Analysis of Efficacy on BMI Reduction. Medical treatment and new medicine, 55(1), 65-9.
[2] Briskey, D., Malfa, G. A., & Rao, A. (2022). Effectiveness of “Moro” Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women—A Randomized Double-Blind Placebo-Controlled Study. Nutrients, 14(3), 427.
[3] Tomasello, B., Malfa, G. A., La Mantia, A., Miceli, N., Sferrazzo, G., Taviano, M. F., ... & Acquaviva, R. (2021). Anti-adipogenic and anti-oxidant effects of a standardised extract of Moro blood oranges (Citrus sinensis (L.) Osbeck) during adipocyte differentiation of 3T3-L1 preadipocytes. Natural Product Research, 35(16), 2660-2667.
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