Are 80% of cholelithiasis asymptomatic? All About Gallbladder-Related DiseasesChung-Ang University Hospital Surgery Professor Hee-Joo Son

Are 80% of cholelithiasis asymptomatic? All About Gallbladder-Related DiseasesChung-Ang University Hospital Surgery Professor Hee-Joo Son

Dec 14, 2024Ehotyshamull Joy

 

1. Types of gallbladder disease

What are the diseases of the gallbladder?

 

There are five main types of gallbladder disease.
1. Cholelithiasis
2. Acute cholecystitis
3. Gallbladder polyps
4. Gallbladder adenomyomatosis
5. Gallbladder cancer
Of these, cholelithiasis is the most frequently occurring gallbladder disease.
2. Gallbladder Disease Statistics
Is gallbladder disease common?
Several studies have shown that up to 15% of the adult population in South Korea has gallstones. In addition, according to the statistics of the National Health Insurance Corporation, the number of patients is steadily increasing. Similarly, there was a 2.5-fold increase in 2018 compared to 2005. As a result, the number of cholecystectomy surgeries has been steadily increasing, and in 2021, the number of multi-frequency surgeries has also increased, with more than 90,000 people undergoing surgery every year.

Western eating habits are believed to be the biggest cause of the outbreak. In Asian countries, it is about 5%, but in the United States, Europe, etc., it is 10~20%, and in Africa, it is almost 65%. While there may be differences by ethnicity, it is believed that dietary habits also have a clear influence. Gallbladder disease, which was originally common in middle-aged people, can also be inferred from the fact that it has recently been found in young people in South Korea. 

 

3. Types of gallstones
What are the types of gallstones and what causes them?

Gallstones can be broadly divided into two types: cholesterol stones and pigmentation stones

The first, cholesterol stones. Common causes include:

- Fatty diets, high-calorie, high-fat diets

- 40s

- Pregnancy/taking oral contraceptives

- Starvation and drastic diets

Second, there are pigmentation stones. The causes of pigmented stones are a little different from cholesterol stones. They are as follows:

- Chronic hemolytic disease

- Biliary tract infections

- Internal diseases e.g. Crohn's disease

 

4. Symptoms caused by gallstones
What are the symptoms of cholelithiasis?
Interestingly, even if you have gallstones, you have less than a 20% chance of having symptoms. That is, asymptomatic is most common. However, you may experience the following symptoms:
1. Frequent body aches
 
2. Cholescolic

It is a squeezing pain in the upper right abdomen and is characterized by a long duration, up to 6 hours. Radiating pain occurs in the shoulders and back, and there is no reaction to gastrointestinal medications or antacids. After a certain period of time, it will improve on its own, but once the pain occurs, it will recur in more than 80% of cases within 1~2 years.

 

3. Multiple complications

Complications such as acute cholecystitis, acute glycoliveritis, and acute pancreatitis may occur.

 

4. Jaundice
 
5. Fever
 
6. Elevated liver levels and elevated pancreatitis levels
5. Diagnostic methods of cholelithiasis
How is cholelithiasis diagnosed?

Diagnosis of cholelithiasis is most accurate by abdominal ultrasoundAbdominal ultrasound has the advantages of having a diagnosis rate of more than 95% for cholelithiasis, not using contrast media, and being accessible because it can be done at the primary clinic. However, the disadvantage is that it requires fasting and it is difficult to identify deep organs such as the pancreas and biliary tract.

Abdominal CT can also be diagnosed. Interestingly, abdominal CT is less visible than ultrasound. In particular, less than 50% of cholesterol stones are found.

 

6. Prophylactic cholecystectomy
When is prophylactic cholecystectomy necessary?

You may need a prophylactic cholecystectomy if:

1. If you have symptoms caused by cholelithiasis

Pain, cholecystitis, chronic digestive disorders that affect the liver, pancreas, or biliary tract

 

2. The occurrence of complications related to gallstones

In case of complications such as cholecystitis, biliary stones, cholangitis, pancreatitis, etc.

 

3. If you have risk factors* for gallbladder cancer

There are three types of cholecystectomy: open, laparoscopic, and umbilical single-channel robotic surgery, but the limitation is that umbilical single-channel robotic surgery is not covered by insurance.

There are three main symptoms that can occur after cholecystectomy.

1. Indigestion and abdominal pain

You will be fine within 1~2 weeks after surgery, but you should be careful because indigestion will get worse if you eat too much.

 

2. Change bowel habits

Unconcentrated bile comes out, resulting in frequent trips to the bathroom, soft stools, and diarrhea.

 

3. Gastroesophageal reflux

It is a reflux of bile into the stomach that disappears spontaneously within 3-6 months after resection.

 *Risk factors for gallbladder cancer:
1. If you have gallbladder stones larger than 3 cm or gallbladder polyps larger than 1 cm

Due to the possibility of malignancy, early resection is required

2. Apprenticeship gallbladder

If the gallbladder wall is calcified and appears white at the time of observation

3. Primary sclerosing cholangitis

This disease is an autoimmune disease* in which inflammation of the bile ducts becomes chronic, causing fibrosis of the bile duct wall, thickening of the bile duct wall, resulting in narrowing of the bile ducts or narrowing of the bile ducts.

4. Cholangiopancreatic duct confluence abnormalities*/Gallbladder biliary malformations

5. Older people, women

Statistically, many studies have shown that older people and women have a higher risk of gallbladder cancer.

7. QnA
Gallbladder disease, I'm curious!

Q.Is there anything I can't eat if my gallbladder is removed?

 

No. The gallbladder is gone, but the bile continues to be secreted, so there is nothing you can't eat.

Q.Does obesity cause a lot of gallbladder disease?

 

I do. If you are obese and have high cholesterol levels, you are more likely to develop gallbladder diseases such as cholesterol stones.

Q.Can chondrical adenomyomatosis develop into cancer?

 

Although cholecystic adenomyomatosis is not cancerous, it is virtually impossible to distinguish it from cancer by ultrasound.

Q.Is gallbladder cancer difficult to detect at an early stage like pancreatic cancer?

 

Yes yes. Since there are no special symptoms other than dyspepsia in most cases, it is usually found in an advanced stage when both the liver and biliary tract have been involved.



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