[Magnesium Efficacy] Natural sedative, three effects of magnesium

Essential nutrient magnesium, relaxes our nerves and muscles.

Magnesium Benefits
1. Relieves migraine frequency and intensity
2.  Increases sleep efficiency, sleep duration, and melatonin
3. Improve Arterial Vascular Endothelial Function

Hello. This is pharmacist Jinny.

What do you think is the most important thing in our life? Recently, while talking to a close family medicine teacher on this topic, I got an interesting answer. It was ' stress and fatigue ' . As I listened, I realized that it is truly an inseparable part of our lives today.

In fact , it is known that about 24% of patients visiting a local hospital complain of fatigue as a major symptom [1]. Fatigue is difficult to define simply because it can occur in various aspects such as mental, physical, and social factors, but in general, it refers to a state in which it is difficult to concentrate or make continuous efforts due to lack of energy or continuous feeling of fatigue for no apparent reason.

Since so many factors have an influence, in order to find the cause of fatigue, it is necessary to closely observe various physical phenomena that accompany the feeling of 'tiredness'. If you feel tired for no apparent reason, your eyes are trembling, your arms and legs are cramped, your heart is pounding, or your nerves are sensitive , you may be lacking in the nutrients we are introducing today.

This nutrient is a cofactor for more than 300 kinds of bio-enzymes, and is a very important mineral that regulates nerve impulse transmission and muscle relaxation Today, let's take a look at magnesium, a nutrient that you should pay attention to when your whole body is sensitively tense and tired.

[1] Korea Centers for Disease Control and Prevention, National Health Information Portal Medical Information <Chronic Fatigue Syndrome>

[2] Ministry of Food and Drug Safety, functional ingredient for health functional food <magnesium>

1. Migraine frequency and intensity relief

As mentioned earlier, magnesium plays a role in regulating nerve impulse transmission and muscle relaxation in our body. Because of this, when you are deficient in magnesium, your muscles tense up. This can lead to muscle spasms, high blood pressure, and spasms of coronary and cerebrovascular vessels . It sounds terrifying, but in reality, you can feel it through physical phenomena such as cramps in your limbs and migraines .\

While it's widely known that eye twitching is a sign of magnesium deficiency, you might be unfamiliar with the link between migraines and magnesium. It has been continuously studied in academia, and in 2016, a research paper was published that comprehensively reviewed the research results reported to the academia. 
In this study, which evaluated the effects of intravenous magnesium administration in 948 patients with acute migraine symptoms and magnesium intake on migraine prevention in 789 patients, a total of 21 studies were evaluated . and relaxation of intensity are reported.

"Intravenous magnesium injection reduces acute migraine attacks within 15 to 45 minutes, 120 minutes, and 24 hours after administration, and oral intake of magnesium alleviates the frequency and intensity of migraine headaches. Magnesium supplementation as part of treatment for migraine relief should be applied."
Reference papers: Chiu, HY, Yeh, TH, Yin-Cheng, H., & Pin-Yuan, C. (2016). Effects of intravenous and oral magnesium on reducing migraine: a meta-analysis of randomized controlled trials. Pain physician, 19(1), E97.
2. Increase sleep efficiency · sleep duration · melatonin

I mentioned earlier that magnesium plays a role in regulating the transmission of nerve impulses and relaxation of muscles in our body. From what has been studied so far, magnesium reduces the secretion of the neurotransmitter acetylcholine, thereby stabilizing the nerves and causing muscle tension. It is known  to relax .
Since acetylcholine is a neurotransmitter that causes contraction, arousal and REM sleep in the digestive system and skeletal muscle , magnesium supplementation is inevitably related to sleep. In this context, Abbasi, B and researchers (2012) conducted a human application study with 46 subjects suffering from primary insomnia (insomnia without a specific cause) according to magnesium intake, sleep efficiency, sleep time, and serum melatonin concentration. It is reported that a significant increase in

"Significant increases in sleep duration, sleep efficiency, serum renin and melatonin levels were observed in the magnesium group. We also observed decreases in magnesium self-test (ISI) scores, time to sleep (SOL), and serum cortisol levels. became."
Reference Papers: Abbasi, B., Kimiagar, M., Sadeghniiat, K., Shirazi, MM, Hedayati, M., & Rashidkhani, B. (2012). The effect of magnesium supplementation on primary insomnia in the elderly: A double-blind placebo-controlled clinical trial. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 17(12), 1161.
3. Improve Arterial Vascular Endothelial Function

Nerve and muscle abnormalities that occur when magnesium is insufficient affect the eyes, brain, sleep, as well as the heart and blood vessels . For this reason, patients with acute myocardial infarction are sometimes treated with magnesium intravenously, and epidemiological evidence that magnesium deficiency adversely affects the health of the coronary arteries that supply blood to the heart muscle has been investigated for over 30 years.

Already in 2000, Shechter, M and researchers evaluated the effect of magnesium supplementation on 50 patients with coronary artery disease. We report that improvements have been confirmed.

"The magnesium intake group showed a significant improvement in blood flow-mediated dilation ability. Also, compared to the control group, the extension of exercise (load) and ST-segment changes on the electrocardiogram were improved in the magnesium intake group."
Reference Papers: Shechter, M., Sharir, M., Labrador, MJP, Forrester, J., Silver, B., & Bairey Merz, CN (2000). Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation, 102(19), 2353-2358.

Today, we learned about magnesium, an essential nutrient that is important for relaxation of nerves and muscles in our body. Data on magnesium intake in Korea have not been confirmed accurately, but according to the results of a survey by the National Institutes of Health in the United States, 48% of Americans are magnesium deficient . .

In particular, in my experience, when I recommended intake to people with suspected magnesium deficiency, it was also a nutrient that showed rapid and accurate improvement in the body's response after intake . As it is a nutrient that exhibits various bodily reactions, those who feel these reactions should consider supplementation.

I hope you have a healthy body and mind. More than that, it was Jinny.