[Lactobacillus Efficacy] 3 reasons to choose a strain that has been sufficiently verified in academia

[Lactobacillus Efficacy] 3 reasons to choose a strain that has been sufficiently verified in academia

Lactobacillus, there are not many proven bacteria

This content is health information about ingredients that are not directly related to a specific product .
Lactobacillus Efficacy
1. Antiviral
2. Functional intestinal disease symptom improvement
3. Immune function enhancement
Hello, I am a pharmacist reading a dissertation.
These days, more and more people are looking for lactic acid bacteria for basic health care. However, did you know that lactic acid bacteria have a variety of strains and their functions vary depending on the combination of the strains, so there are not many strains that have been verified in academia?

Today, we will look at the representative strains and functions of two representative strains verified through continuous research in academia,  Lactobacillus acidophilus and bifidobacterium lactis .
1. Antiviral
Methods of suppressing human infection by viruses are continuously being studied. In particular, research on materials that can protect the mucosal cell wall, which are vulnerable to infection, are continuing, and  surface layer protein is attracting attention as a type of protective material. 

Focusing on the fact that this surface layer protein is commonly found in bacteria of the genus Lactobacillus,   a paper on the antiviral mechanism of Lactobacillus acidophilus was published in Front Microbiol in  2019 .
"The surface layer (S-layer) protein present in the cell membrane of Lactobacillus acidophilus can inhibit viral and bacterial infections by blocking the interaction of dendritic cell-specific intercellular adhesion molecules with pathogens "
Reference Paper: Mariano Prado Acosta, Eileen M. Geoghegan, Bernd Lepenies, Sandra Ruzal, Margaret Kielian, Maria Guadalupe Martinez (2019) "Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction" Front Microbiol. 10, 810.
2. Improve symptoms of functional bowel disease
The influence of the gut flora on the pathogenesis of functional bowel disease is a strong academic hypothesis. Accordingly, research has been actively conducted since the 2010s to find combinations of bacterial species and strains that  can contribute to the improvement of intestinal diseases by changing the composition of the intestinal flora  .

The paper I will introduce now is a paper published in J Clin Gastroentero in 2011.  NCFM, a representative strain of Lactobacillus acidophilus, and Bi, a representative strain of Bifidobacterium lactis.We are reporting the results of a clinical trial evaluating the effect of the combination of -07 on the improvement of functional bowel disease . 
The fact that a significant decrease in the severity of abdominal bloating symptoms was consistently observed in the experimental group compared to the control group at both 4 and 8 weeks after the intervention, suggesting a significant impact of probiotic supplementation on the improvement of abdominal bloating "
References: Yehuda Ringel, Tamar Ringel-Kulka, Danielle Maier, Ian Carroll, Joseph A Galanko, Gregory Leyer, Olafur S Palsson (2011) "Clinical trial: Probiotic Bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Versus Placebo for the Symptoms of Bloating in Patients with Functional Bowel Disorders - a Double-Blind Study" J Clin Gastroenterol. 45(6): 518–525
3. Strengthen immune function
Many of you now know that lactic acid bacteria can contribute to strengthening the immune system. As reports on the enhancement of immune function of lactic acid bacteria continue to accumulate in academia,  research is continuing to elucidate the types of bacteria that contribute to the enhancement of immune function and their mechanisms. 

A paper published in J Nutr Sci in 2013  reveals the immune function enhancement mechanism of Bi-07, a representative strain of Bifidobacterium  lactis , and suggests the implications of this mechanism for elderly health care . 
Supplementation of live Bi-07 cells may provide long-term health benefits to the elderly by enhancing the innate immune defense against infection but not causing inflammation-related metabolic disorders. "
References: Sujira Maneerat, Markus J. Lehtinen, Caroline E. Childs, Sofia D. Forssten, Esa Alhoniemi, Milin Tiphaine, Parveen Yaqoob, Arthur C. Ouwehand, and Robert A. Rastall (2013) “Consumption of Bifidobacterium lactis Bi- 07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes", J Nutr Sci. 2, e44.

Above, we briefly reviewed the functions of major strains and strains that have been verified in the academic world.


I hope you have a healthy day in body and mind. More than that, it was Jinny.

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