[Efficacy of Rosemary Extract Complex (SunMax)] Wrinkle improvement? 3 Benefits of Rosemary Extract

Introducing 'this ingredient', the strongest anti-aging agent

Efficacy of complex (SunMax) such as rosemary extract
1. Glabellar ∙ Nasolabial fold ∙ Mouth ∙ Marionette wrinkle formation improvement
2. Photoaging prevention
3. Anti-inflammatory

This is Jinny, the pharmacist.

Anti-aging, truly a mind-boggling magic word. Many people, including me, must be looking for a way to effectively delay skin aging. The mechanism of action of the new skin health material 'Rosemary Extract Complex (SunMax)', which has recently been recognized as an individually approved functional ingredient for skin health by the Ministry of Food and Drug Safety, and the human body The results of the application test are not serious, so I would like to introduce them today. 


Theoretically, two types of care are needed for effective anti-aging . One is to supplement the three major elements of the dermis that decrease with aging of the body, and the other is to prevent extrinsic aging (photoaging) caused by ultraviolet rays as much as possible . For this reason, it is recommended to supplement collagen and elastin, which decrease with aging, and this is also why dermatologists emphasize the importance of sunscreen.

So far, I have introduced ingredients that have advantages in managing endogenous aging, such as collagen, elastin, and salmon DNA, and ingredients that have advantages in managing extrinsic aging, such as glutathione. , so I had no choice but to expect relatively indirect benefits. However, the functional raw material rosemary extract and other complexes (SunMax) to be introduced today are not only recognized for their ability to maintain skin health from photoaging, but are also confirmed to improve four types of wrinkles in human body application tests .

Let's take a closer look at the efficacy of this direct anti-aging new material.

1. Glabellar ∙ Nasolabial folds ∙ Mouth ∙ Marionette wrinkle formation improvement

A typical symptom of skin aging is wrinkles. Both intrinsic and extrinsic aging leave wrinkles, but intrinsic aging is characterized by fine lines, while extrinsic aging by UV rays is characterized by deep and thick wrinkles. Therefore, as an anti-aging ingredient that manages extrinsic aging caused by ultraviolet rays, the function of improving wrinkle formation can be said to be quite important. 

As a result of a human application test targeting adult men and women with wrinkles around the eyes, mild or moderate nasolabial folds, it was confirmed that intake of a complex (SunMax) such as rosemary extract improved wrinkle formation in four areas of the face. .

"As a result of ingesting a complex such as rosemary extract (225 mg/day) for 13 weeks, wrinkle formation (glabella, nasolabial folds, Marionette wrinkles, wrinkles around the mouth), visual evaluation by a dermatologist (erythema, itching), subjective skin evaluation ( facial wrinkles) was significantly reduced compared to the control group"
Source: Ministry of Food and Drug Safety, Consumer Report on Functional Raw Materials for Health Functional Foods (draft) – Rosemary Extract, etc. Complex [No. 2021-18]
2. Anti-photoaging

As mentioned earlier, the main cause of extrinsic aging is UV rays. The word 'photoaging', which refers to skin aging caused by ultraviolet rays, is used interchangeably with 'extrinsic aging' in almost the same meaning. When exposed to UV rays, reactive oxygen species increase and collagen and elastin degradation enzymes are expressed. As a result, skin elasticity decreases and skin wrinkles occur.

As such, how the complex (SunMax), including rosemary extract, protects the skin from skin damage caused by photoaging has become a major review task . A research result has been reported in the academic world that suppresses the expression of collagenase (MMP-1) by ultraviolet rays in human fibroblasts .
"Carnosic acid, a polyphenolic antioxidant, showed inhibition of UVA-induced collagenase (MMP-1) expression."
Reference paper: Offord, EA, Gautier, JC, Avanti, O., Scaletta, C., Runge, F., Krämer, K., & Applegate, LA (2002). Photoprotective potential of lycopene, β-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radical Biology and Medicine, 32(12), 1293-1303.
3. Anti-inflammatory

UV rays not only cause skin aging by decomposing collagen and elastin, but also generate various proinflammatory cytokines by increasing active oxygen, and promote cell necrosis and apoptosis by the inflammatory cytokines produced in this way. As a result, not only skin elasticity but also the overall condition of the skin deteriorates. 

The reason why the complex (SunMax), such as rosemary extract, which inhibits the expression of collagenase by UV rays, is special is that anti-inflammatory effects can also be expected. According to the results of a study in 2012, the anti-inflammatory benefits of the composition of carnosic acid and lutein, which are the key ingredients of the complex (SunMax), such as rosemary extract, were confirmed.

"The composition of lutein and carnosic acid showed an upper limit synergistic inhibition (80%) of the activity of NF-κB. These results indicate a significant synergistic effect of the two components."
Reference paper: Hadad, N., & Levy, R. (2012). The synergistic anti-inflammatory effects of lycopene, lutein, β-carotene, and carnosic acid combinations via redox-based inhibition of NF-κB signaling. Free Radical Biology and Medicine, 53(7), 1381-1391.

Today, we looked at a complex (SunMax), including rosemary extract, an ingredient that is not lacking in being called the strongest exogenous anti-aging, from wrinkle improvement to photoaging prevention. I think many people are taking collagen and elastin for anti-aging. As much as taking care of the components of the dermis that decrease due to aging, if you pay attention to preventing destruction by UV rays, you can prevent skin aging more effectively. It seems possible.

I hope you have a healthy day in body and mind. It was Jinny.