[Efficacy of Morosil®] 3 effects of Morosil®, from weight loss to anti-lipogenesis

Introducing 'This Ingredient', the ultimate diet supplement

Morosil®  Benefits
1. Weight ∙ BMI ∙ Waist circumference ∙ Hip circumference decreased
2. Abdominal fat ∙ Visceral fat ∙ Subcutaneous fat decreased
3.  Inhibiting Lipogenesis

This is Jinny, the pharmacist.

Fall is the season of high fever that has come again this year. In fact, in autumn, as the amount of sunlight decreases, serotonin secretion decreases, so appetite increases and the desire to consume carbohydrates increases. As the temperature drops again, our body wants to accumulate subcutaneous fat. It is true that these changes that last from autumn to early spring are not welcome.

Today, from autumn to spring, where it is easy to gain weight, We would like to introduce cutting-edge diet materials that can be consumed for a long time and manage body fat . It is Morosil (Morosi l ® , a vegetable diet ingredient extracted from Moro oranges from the Etna Volcanic Zone in Sicily Morosil®, which contains  C3G, a type of anthocyanin abundant in Moro oranges, as a key ingredient,This ingredient has not only been recognized for its body fat reduction functionality by the Ministry of Food and Drug Safety, but also has been confirmed to improve 7 indices related to diet according to intake in a human application test . Let's take a closer look at the effectiveness of this new diet material.

1.  Decreased weight ∙ BMI ∙ waist circumference ∙ hip circumference

In the past, if there were many people who checked their weight (kg) when dieting, these days, the main diet is to maintain a healthy and balanced body line while paying attention to body weight, BMI, and 'eye body' that can be seen with the naked eye. It became a purpose. Accordingly, when evaluating the benefits of functional ingredients in a diet, whether or not they can contribute to 'eye body' beyond weight loss has emerged as a key evaluation factor.


In 2018, Medical treatment and new medicine reported the results of a human application test that evaluated the benefits of Morosil® intake in 60 non-obese adults with a BMI of 27. In this study, it is reported that a reduction of about 7cm in waist circumference and 6cm in hip circumference as well as weight and BMI reduction was observed following 12-week intake of 400mg/day of Morosil® .

"In conclusion, we found that 12-week intake of Morosil® contributed to weight loss, improvement in BMI, and reduction in waist and hip circumference, even in non-obese subjects. In addition, during the 12-week trial period, There were no safety issues."
Reference paper: Kaneko, T., & Shikarawa, TA (2018). Study on Supplement Containing Moro (Citrus Sinensis (L.) Osbeck) Orange Extract of a Randomized Placebo-controlled Trial Part 2: Analysis of Efficacy on BMI Reduction. Medical treatment and new medicine, 55(1), 65-9.
2. Abdominal fat ∙ visceral fat ∙ subcutaneous fat reduction

Unlike diets to satisfy individual subjective aesthetic tastes and desires for self-expression, there are diets that are essential for our body's health. It is the management of abdominal and visceral fat. In particular, visceral fat, which accumulates in the abdominal cavity and around the intestines, can increase the risk of cardiovascular disease and diabetes due to metabolic syndrome, hyperlipidemia, and insulin resistance if the amount is large. is required.


As such, management of visceral fat has a high importance in maintaining health, and whether Morosil®, which has begun to be known as a new diet material, can contribute to managing visceral fat has become a major review task in the academic world, published in Nutrients in 2022. In the human body application test, it is reported that BMI, waist and hip circumference, as well as abdominal fat, visceral fat, and subcutaneous fat improvement were confirmed following intake of Morosil® .

"Fat mass and fat distribution (visceral fat and subcutaneous fat) were both significantly improved in the Morosil® intake group compared to the placebo group. In addition, all safety indicators related to hepatotoxicity did not deviate from the normal range throughout the study. "
Reference paper Briskey, D., Malfa, GA, & Rao, A. (2022). Effectiveness of “Moro” Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women—A Randomized Double-Blind Placebo-Controlled Study. Nutrients, 14(3), 427.

 

3. Inhibiting Lipogenesis

Morosil®, which has been confirmed to have various benefits related to diet in human application tests, how does it work? In a research report published in Natural Product Research in 2021, the body fat reduction mechanism of Morosil® is revealed as an anti-lipogenic activity based on antioxidant capacity .

Adipogenesis refers to the process by which fat cells, or fat cells, develop and accumulate as adipose tissue in various parts of the body. If you continuously consume more energy than you consume, tissue fat cells not only increase in number but also enlarge in size. This study elucidates the mechanism by which Morosil® inhibits this lipogenesis process.

"The results of this study show that Morosil® exerts antioxidant and antiadipogenic activity during the differentiation of preadipocytes into adipocytes."
Reference paper: Tomasello, B., Malfa, GA, La Mantia, A., Miceli, N., Sferrazzo, G., Taviano, MF, ... & Acquaviva, R. (2021). Anti-adipogenic and anti-oxidant effects of a standardized extract of Moro blood oranges (Citrus sinensis (L.) Osbeck) during adipocyte differentiation of 3T3-L1 preadipocytes. Natural Product Research, 35(16), 2660-2667. 

 

Today, we looked at the intake benefits of Morosil®, a new cutting-edge diet material obtained from the Etna volcanic region in Sicily, and the mechanism of body fat reduction. As many studies suggest that it can be consumed not only for diet but also for preventing overweight and obesity, it would be good to use it in the fall and winter when body fat tends to increase, just like clothes getting wet in drizzling rain.

I hope you have a healthy day in body and mind. It was Jinny.