[Efficacy of lemon balm and dandelion extract complex (LD100)] Three effects of LD100, an advanced ingredient that protects liver cells

LD100, a state-of-the-art liver health functional ingredient

Lemon balm dandelion extract complex (LD100) efficacy
1. Liver protection from alcoholic liver damage
2. Improvement of liver levels (AST ∙ GGT)
3. Inhibition of fat accumulation in hepatocytes

This is Jinny, the pharmacist.

When you think of liver health, what ingredient comes to mind first? I think many people, including myself, reflexively thought of milk thistle. Milk thistle has been used as a treatment for jaundice, stone removal, and snakebite in Europe since around the 1st century, and has been steadily used as an adjuvant treatment for liver disease since 1968 when its active ingredient was confirmed [ One].

So, for the past 50 years, the representative ingredient for liver health has been 'Milk Thistle Extract'. However , in 2020, an interesting research result was published in the Journal of Food Biochemistry , an SCI-level international academic journal . In suppressing alcohol-induced hepatic steatosis, the high-tech raw material 'this ingredient' showed a more excellent effect than milk thistle extract (silymarin) [2].

For those who drink frequently, 'this ingredient' that you should focus on is the functional ingredient lemon balm and dandelion extract complex (LD100) that we are going to introduce today . As the name suggests, this raw material, which is formulated with lemon balm extract and dandelion extract at the ratio that showed the highest activity in a test study, is also the latest individually recognized liver health functional raw material recognized by the Ministry of Food and Drug Safety .

So today, let's take a look at the academic research on lemon balm and dandelion extract complex (LD100) to find out what mechanism and test results have been confirmed to be superior to milk thistle extract, which has been synonymous with health functional raw materials for 50 years. I'll do it.

[1] Gillessen, A., & Schmidt, HHJ (2020). Silymarin as supportive treatment in liver diseases: A narrative review. Advances in therapy, 37(4), 1279-1301.

[2] Choi, BR, Cho, IJ, Jung, SJ, Kim, JK, Park, SM, Lee, DG, ... & Park, KM (2020). Lemon balm and dandelion leaf extract synergistically alleviates ethanol ‐ induced hepatotoxicity by enhancing antioxidant and anti ‐ inflammatory activity. Journal of Food Biochemistry, 44(8), e13232.

 

1. Liver protection in alcoholic liver damage

Drinking itself is not bad, but excessive alcohol consumption is one cause of poor health. In fact , it is reported that alcohol consumption was the main cause of death in 3.8% of deaths worldwide . In particular, alcoholic liver disease is one of the important causes of death from liver disease, and is highly correlated with increased alcohol intake and intake time [3].

This sounds like someone else's business, but in fact, more than 90% of people who drink too much are observed to have fatty liver, and there are also research reports that 30% will suffer from alcoholic liver disease . It is known that it is caused by the generation of free radicals, mitochondrial damage, and steatosis, which are common characteristics of acute and chronic alcohol exposure [4].

[3,4] Li, S., Tan, H.Y., Wang, N., Zhang, ZJ, Lao, L., Wong, C.W., & Feng, Y. (2015). The role of oxidative stress and antioxidants in liver diseases. International journal of molecular sciences, 16(11), 26087-26124.


For this reason, one of the most important items to be reviewed for the efficacy of functional ingredients for liver health is the effectiveness of inhibiting liver damage caused by alcohol. In 2020, the Journal of Food Biochemistry , an SCI-level international journal , confirmed the protective effect of lemon balm dandelion extract complex (LD100) against alcoholic liver damage and announced that it was superior to milk thistle extract in terms of effectiveness.

"The hepatoprotective effect of the lemon balm and dandelion extract complex on alcoholic liver damage was superior to that of milk thistle extract and lemon balm and dandelion single extracts. ... This fact indicates that the lemon balm and dandelion extract complex is effective for preventing alcohol-induced liver damage. It proves that he is a promising candidate."
Reference paper:  Choi, BR, Cho, IJ, Jung, SJ, Kim, JK, Park, SM, Lee, DG, ... & Park, KM (2020). Lemon balm and dandelion leaf extract synergistically alleviates ethanol ‐ induced hepatotoxicity by enhancing antioxidant and anti ‐ inflammatory activity. Journal of Food Biochemistry, 44(8), e13232.
2. Improvement of liver values ​​(AST ∙ GGT)

According to the academic report on the excellent hepatoprotective activity of lemon balm and dandelion extract complex (LD100) in alcoholic liver damage, whether the efficacy of this ingredient is limited to alcoholic liver damage, or in a broader dimension such as general liver health deterioration Additional studies were designed to  examine whether it may contribute to improving liver health .

In this study, 96 adults with liver levels between about 110 and 320 percent of the upper limit of normal* were enrolled , despite not consuming excessive amounts of alcohol, having liver disease, or taking other drugs that could cause liver damage. As a result of a 12-week human application test with subjects, it is reported that significant decreases in AST and GGT, which are major liver function test markers, were confirmed following the intake of lemon balm and dandelion extract complex (LD100) .

*Liver value upper limit of normal: based on ALT 33 IU/L

"Through this human application test, it was confirmed that intake of LD100 500mg/day for 12 weeks has the function of improving liver function by reducing blood AST and GGT in subjects with mild liver function decline. Also, during the study, clinically No significant adverse reactions or body changes were observed, so it was judged that the intake of LD100 was safe for the human body. "
Reference thesis: LD100 human application test report '12-week, randomized, double-blind, placebo comparative human application test to evaluate the efficacy and safety of LD100 in improving liver function in subjects with mild liver function impairment'

 

3. Inhibition of fat accumulation in hepatocytes

Earlier, I told you that fatty liver is observed in more than 90% of people who drink excessively. Fatty liver refers to a state in which fat is accumulated in liver cells, and excessive drinking, obesity (abdominal obesity), diabetes, and hyperlipidemia are pointed out as the main causes of fatty liver. It is very common, but it can go unnoticed because there are no specific symptoms. 

However , if the root cause of fatty liver is not corrected, it can progress to liver cirrhosis through fatty hepatitis and liver fibrosis, so proper management is needed. According to the mechanism study, the lemon balm dandelion extract complex inhibits liver lipid accumulation through suppression of liver lipid formation genes and increased expression of genes involved in liver lipid oxidation, so it seems to be helpful in managing fatty liver.


Already in 2019, Choi Beom-rak and researchers evaluated the effect of lemon balm and dandelion extract complex on non-alcoholic acute liver injury induced by carbon tetrachloride. In this study, it was confirmed that the relative weight of the liver decreased according to the treatment with the lemon balm and dandelion extract complex (LD100), and these effects were reported to be superior when compared to the treatment with milk thistle extract, lemon balm, and dandelion alone.

"Administration of mixed ratio of lemon balm and dandelion leaf extract statistically significantly suppressed the increase in liver relative weight due to liver toxicity, ... than milk thistle extract (silymarin), lemon balm alone, and dandelion alone administration groups It further reduced the relative weight of the liver."
Reference paper:  Choi, BR, Cho, IJ, Jung, SJ, Kim, JK, Lee, DG, Ku, SK, & Park, KM (2019). Study on the hepatoprotective effects of lemon balm and dandelion leaf extract combination in carbon tetrachloride-mediated liver injured mice. Herbal formula science, 27(3), 199-211.

Today, we looked at the results of academic research on lemon balm and dandelion extract complex (LD100), a new material for liver health. Unlike milk thistle extract, which contributes to detoxification by improving the antioxidant activity of liver tissue based on its antioxidant and anti-inflammatory activities, Lemon Balm Dandelion Extract Complex (LD100) contains lemon balm extract that works to improve lipid metabolism and antioxidant and anti-inflammatory properties. The synergistic action of dandelion extract, which acts on inflammation, seems to contribute to liver health.

In summary, if you want to manage liver health intensively, choose lemon balm dandelion extract complex (LD100), and if you want to reduce the burden of liver detoxification and get help with antioxidants, choose milk thistle extract . I think it will be helpful to use each ingredient appropriately.

In addition, both milk thistle extract and lemon balm dandelion extract complex (LD100) are recommended to be avoided for children under the age of 12. In addition, if you are undergoing treatment for a disease or taking medicines, it is recommended that you make a decision to take it through consultation with your doctor.

I hope you have a healthy day in body and mind. It was Jinny.