[Effects of Inositol] Essential for women of childbearing age, 3 effects of inositol

Inositol efficacy
1. Improves insulin resistance
2. Reduces ovulation induction period
3. Induction of regular menstruation

Hello. This is Jinny, the pharmacist.

Polycystic ovarian syndrome is a health concern for many women of childbearing age. Polycystic ovary syndrome is an endocrine disorder that is common in women of childbearing age. It refers to abnormal ovulation, clinically symptomatic symptoms of excessive male hormones, or polycystic ovaries observed on ultrasound. Patients with polycystic ovary syndrome may experience infertility due to abnormal menstruation and ovulatory disorders, and may also have insulin resistance and hirsutism.

Recently, as it is known that inositol intake can help these symptoms of polycystic ovarian syndrome, more and more people are looking for inositol. Inositol is a substance that composes phospholipids of cell membranes in our body and is involved in signal transduction and insulin metabolism.

So today, we will take a closer look at exactly what benefits inositol has through a paper.

1. Improves insulin resistance

Insulin resistance is a phenomenon in which cells cannot effectively burn glucose due to the inability of insulin to lower blood sugar. When insulin resistance increases , glucose production in the liver is not regulated, and glucose utilization in muscle or storage as fat is not good, so blood sugar remains high . Because high insulin resistance is also a very important symptom of polycystic ovary syndrome, women with polycystic ovary syndrome are known to have a higher risk of developing type 2 diabetes than women without it. 

In this regard, a paper was published in Gynecological Endocrinology in 2017 that studied the effect of inositol on insulin resistance .

" On day 21 after 12 weeks of myoinositol (MYO) administration, serum progesterone (female hormone) levels increased significantly, and fasting insulin, fasting glucose, and homeostasis model of insulin resistance (HOMA-IR) decreased. "
Reference paper: Özlen Emekçi Özay, Ali Cenk Özay, Erkan Çağlıyan, Recep Emre Okyay & Bülent Gülekli (2017) Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial. Gynecol Endocrinol. 33(7):524-528. 
2. Reduces ovulation induction period

When women are preparing for conception, they often check their ovulation cycle. This is because ovulation is the time when an egg is released from the ovary and is an important step in enabling pregnancy. Therefore , if ovulation does not occur normally, it may cause infertility .

In this regard , a paper was published in 2017 that showed that the ovulation induction period was significantly shortened when inositol was consumed .

“ Administration of myoinositol (MYO) increases clinical pregnancy rates and reduces total r-FSH (follicle stimulating hormone) dose and duration of induction of ovulation. "
Reference paper: Özlen Emekçi Özay, Ali Cenk Özay, Erkan Çağlıyan, Recep Emre Okyay & Bülent Gülekli (2017) Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial. Gynecol Endocrinol. 33(7):524-528.
3. Induction of regular menstruation

Healthy women of childbearing age usually menstruate every 26-32 days. On the other hand, amenorrhea, a representative symptom of polycystic ovarian syndrome, refers to a woman who has had menstruation who has not menstruated for more than three times the past menstrual cycle or has not menstruated for more than 6 months 

In this regard, a paper published in Gynecological Endocrinology in 2007 revealed the results of a study that women with polycystic ovary syndrome recovered their menstrual cycle when they ate inositol .

“ Twenty-two (88%) of 25 patients recovered at least one spontaneous menstrual cycle during treatment, and 18 (72%) of these patients maintained normal ovulatory activity during the follow-up period. "
Reference papers: ENRICO PAPALEO, VITTORIO UNFER, JEAN-PATRICE BAILLARGEON, LUCIA DE SANTIS, FRANCESCO FUSI, CLAUDIO BRIGANTE, GUIDO MARELLI, ILARIA CINO, ANNA REDAELLI, & AUGUSTO FERRARI. (2007) Myo-inositol in patients with polycystic ovary syndrome: A novel method for ovulation induction. Gynecological Endocrinology. 23(12): 700–703.

Today, through a paper, we looked at the benefits of inositol intake. Lastly, if you are overweight or obese and have polycystic ovarian syndrome, losing weight will help improve symptoms, so it is recommended that you manage your diet and exercise at the same time.

I hope you have a healthy day in body and mind. It was Jinny.