[Boulardii's Efficacy] For those who do not have the effect of lactic acid bacteria, Yeast bacteria to combat harmful bacteria

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Boulardii's Efficacy
1. Inhibition of growth of harmful bacteria
2. Anti-Candida bacteria
3. Anti-inflammatory
Hello. A pharmacist who reads a dissertation. 
I think many people are basically consuming lactic acid bacteria.
However, there are quite a few people who feel uncomfortable  because they eat lactic acid bacteria and do not feel any effect, or  have gas or constipation in their stomach  . This is because each person has a different balance of intestinal flora. 
Today, I would like to introduce several benefits of Saccharomyces boulardii (hereafter bouladi) ,  yeast that creates an intestinal environment where lactic acid bacteria can settle well  for these people  .
1. Inhibit the proliferation of harmful bacteria
Unlike lactic acid bacteria, which belong to bacteria, bowllady is a yeast, so it  has the characteristic of surviving in external environments such as high temperature, stomach acid, and bile acid Therefore, most of the bouladi we ingested  reach the intestines alive.
 
Due to these properties of  Bowladi, studies on the complementary action with lactic acid bacteria  are accumulating. In particular, the interest of the academic community is continuously accumulating due to the characteristics of  Bowladi , which survives in environments where the survival of beneficial bacteria in the body is difficult,  such  as taking antibiotics for a long period of  time.
 
In March 2021, Front Public Health reported  that when lactobacilli and bouladi were taken together, it was possible to suppress the growth of harmful bacteria caused by antibiotic prescription  .
“ Combined intake of certain strains of Lactobacillus and Bifidobacterium  and Saccharomyces boulardii  influences antibiotic therapy by counteracting the colonization of antibiotic-resistant pathogenic  microflora  . ”
Reference Papers: Grégoire Wieërs, Valérie Verbelen, Mieke Van Den Driessche, Ekaterina Melnik, Greet Vanheule, Jean-Christophe Marot and Patrice D. Cani (2020). Do Probiotics During In-Hospital Antibiotic Treatment Prevent Colonization of Gut Microbiota With Multi-Drug-Resistant Bacteria? A Randomized Placebo-Controlled Trial Comparing Saccharomyces to a Mixture of Lactobacillus, Bifidobacterium, and Saccharomyces. Front Public Health 2020.
2. Anti-Candida
Bowllady, which survives even in such an extreme environment,  is known to be excellent  in inhibiting the growth of harmful bacteria  . Accordingly, hospitals often prescribe it as an antibiotic to improve the side effects of patients  receiving antibiotic treatment  .

However, the action of  bouladi is not limited to improving gut health. Typically, bouladi  contributes to general health through its ability to inhibit Candida bacteria. Candida is a major causative agent of vaginosis,  a harmful bacterium that travels throughout the body through the bloodstream,  causing skin diseases and gastroesophageal reflux disease  .
 
The 2009 FEMS Yeast Research  report on the anti-Candida mechanism of  Bowladi as follows.
“ The ability of Saccharomyces bouladi extract to control major Candida virulence factors is (omitted) very significant and can be applied in treatment for Candida-induced infections. ”
Reference paper: Anna Krasowska, et al. (2009), The antagonistic e¡ect of Saccharomyces boulardii on Candida albicans filamentation, adhesion and biofilm formation, FEMS Yeast Research, 9, 1312–1321.
3. Anti-inflammatory
Additionally, boulardi has  been shown to play an important role in the body's immune system.
 
A paper published  in FEMS (Federation of European Microbiological Societies) in  2010  revealed that Saccharomyces boulardii  had anti-inflammatory action by regulating cytokines secreted by immune cells .
“ Our study suggests that  Saccharomyces bouladi (omitted)  reduces cytokine-mediated inflammatory host responses. "
References: Anna Murzyn, Anna Krasowska, Daria Augustyniak, Grazyna Majkowska-Skrobek, Marcin Łukaszewicz, Dorota Dziadkowiec (2010). The effect of Saccharomyces boulardii on Candida albicans-infected human intestinal cell lines Caco-2 and Intestin 407. FEMS Microbiol Lett 310, 17–23.
Today we looked at Boulderdi. It is very safe and has various benefits, but  due to the nature of yeast, those who have extremely low immunity,  or those who have taken steroids or immunosuppressants for a long time  , should be careful about intake. 
 
Also, unlike lactic acid bacteria, bowllady cannot settle in the intestines and live, so  continuous intake is recommended. If you are worried about not seeing the effects of the lactic acid bacteria you have  been eating , how about choosing a lactobacillus containing Bowladi?
I hope you have a healthy body and mind. More than that, it was Jinny.